Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single-Cell Resolution. (PubMed, Cell Prolif) - Nov 28, 2025 - "A gene regulatory network analysis highlighted JUN as a key regulator mediating proliferation inhibition, primarily active in the apoptotic cell subcluster. These findings illustrate how integrating high-throughput screening with mechanistic dissection can accelerate the discovery of targeted drug combination therapies, and offer a blueprint for precise interventions using pathway vulnerabilities and cellular heterogeneity in HCC."
Journal • Hepatocellular Cancer • Oncology • Solid Tumor
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Bin Xu; Guangyan Li; Guoji Guo; Guoxia Wen; Haide Chen; Jingjing Wang; Junqing Wu; Mengmeng Jiang; Tingyue Zhang; Wenzhao Zhou; Xiaoping Han; Xudong Fu; Yuqing Mei
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