Transcriptional condensates enrich phosphorylated PRMT2 to stimulate H3R8me2a deposition and hypoxic response in glioblastoma. (PubMed, Sci China Life Sci) - Sep 10, 2025 - "Moreover, the combination of TG02 and temozolomide, the standard chemotherapy for GBM, significantly inhibits tumor progression in mouse xenograft models, an effect partially mediated by targeting PRMT2S12 phosphorylation. Our study uncovers the role of transcriptional condensation in enhancing PRMT activity, reveals a new mechanism for CDK9 inhibitors in modulating context-dependent transcriptional programs, and proposed a combinatorial therapeutic strategy against GBM."
Journal • Brain Cancer • Glioblastoma • Oncology • Solid Tumor • PRMT2
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Feng Dong; Jiaxiang Wan; Qian Li; Wei Li; Weijian Du; Xiaoyu Sun; Xuan Cheng; Xudong Wu
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