Cysteine-based molecular switches: a focus on KEAP1 and BACH1 in regulating the antioxidant response. (PubMed, Arch Toxicol) - Oct 8, 2026 - "Cysteine modifications within KEAP1 and BACH1 render the repressor proteins inactive, resulting in rapid NRF2 activation that does not rely on de novo transcription of NFE2L2, the gene encoding NRF2. Consequently, NRF2 induces the transcriptional upregulation of a large network of genes encoding cytoprotective proteins, many of which have antioxidant functions, restoring the redox homeostasis."
Journal • Review • Targeted Protein Degradation • BACH1 • BRIP1 • KEAP1
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Albena T Dinkova-Kostova; Jialin Feng
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