Genetic ALS-Progressive Sleep Defects Precede the Onset of Clinical Disease. (PubMed, Eur J Neurol) - Sep 22, 2026 - "Sleep macro- and microarchitectural abnormalities progressively worsen during the premanifest phase of ALS. These findings suggest that polysomnography-derived sleep measures and their neurochemical correlates may serve as sensitive, noninvasive surrogate biomarkers of disease progression in clinically silent ALS. This could support disease prevention, for example, by the antisense oligonucleotide tofersen in patients carrying SOD1 mutations."
Journal • Observational data • Amyotrophic Lateral Sclerosis • CNS Disorders • Sleep Disorder • SOD1
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Albert C Ludolph; Antje Knehr; Christina Lang; Hayrettin Tumani; Johannes Dorst; Luc Dupuis; Matei Bolborea; Patrick Weydt; Simon J Guillot
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