Dual promoter architecture of NFE2L2 underlies isoform-specific translational control of NRF2. (PubMed, Redox Biol) - Sep 22, 2026 - "The extended P2-specific 5'UTR contains evolutionarily conserved structural features that may contribute to translational regulation. Finally, the electrophilic NRF2 activator omaveloxolone (RTA-408) induced translation of transcripts from both promoters, demonstrating that NRF2 stress response is coordinated through the combined regulation of mRNA translation and protein stability."
Journal • Oncology • KEAP1
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Alicja Sznarkowska; Artur Piróg; Ines Papak; Kevork Wakimian; Natalia Marek-Trzonkowska; Witold Rzyman; Zuzanna Urban-Wójciuk
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