Antibody-Dependent Cellular Phagocytosis and Cytotoxicity in Patients With LGI1 and CASPR2 Encephalitis. (PubMed, Neurol Neuroimmunol Neuroinflamm) - Sep 24, 2026 - "ADCC and ADCP, but not CDC, are common effector functions of LGI1/CASPR2-IgG, and their presence correlates with long-term poor outcome, suggesting that they might represent a useful prognostic biomarker and suggest additional pathogenic mechanisms. We provide the proof- of principle for a framework that could be applied to other autoantibody-mediated disorders."
IO biomarker • Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Immunology
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Alvino Bisecco; Antonella Toriello; Antonio Malvaso; Carla Arbasino; Carmela Leone; Chiara Morandi; Denise Cerne; Diego Franciotta; Elisabetta Zardini; Enrico Marchioni; Federica Zuliani; Francesco Fattapposta; Irene Volonghi; Luana Benedetti; Marco Currò-Dossi; Marianna Spatola; Matteo Gastaldi; Paolo Barone; Pietro Businaro; Sara Micheli; Silvia Casagrande; Silvia Cenciarelli; Silvia Scaranzin; Stefano Masciocchi; Stefano Nassani
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