LAMA5 pathogenic variant uncovers a novel autoantigen in membranous nephropathy. (PubMed, Genes Dis) - Sep 21, 2026 - "Notably, rituximab treatment in the patient led to the disappearance of anti-Laminin α5 autoantibodies and sustained clinical remission. Our findings establish Laminin α5 as a novel genetic autoantigen in membranous nephropathy and suggest that screening for anti-Laminin α5 antibodies may help identify patients who could benefit from B-cell-targeted therapies."
Journal • Glomerulonephritis • Nephrology • Pediatrics • Renal Disease • LAMA5
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Chenyang Xiong; Haiping Yang; Han Xiao; Hui Yin; Lan Qiu; Qinqin Tan; Qiu Li; Wanbing Chen; Wei Jiang; Xindi Zhou; Xuejun Yang; Yulu Shi
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