Mycophenolate Mofetil Modulates Memory B Cells and Plasmablasts Without Persistent Impairment of Immunological Memory in Pediatric Steroid-Sensitive Nephrotic Syndrome (KIDNEY WEEK 2026) - Oct 2, 2026 - Abstract #FR-PO0835; Pres time: Oct 23, 2026; 10:00 AM - 12:00 PM; Location: Exhibit Hall A, Convention Center; "Background Despite the initial response to standard prednisone (PDN) therapy, children with steroid-sensitive nephrotic syndrome (SSNS) frequently experience relapses requiring intensified immunosuppression (IS), including repeated PDN cycles or second-line agents such as mycophenolate mofetil (MMF), calcineurin inhibitors (CNIs), or rituximab (RTX), which may induce prolonged impairment of humoral immunity. Anti-nephrin autoantibodies were detected in most patients at onset and declined after remission regardless of maintenance therapy. Conclusion Both MMF and RTX significantly reduced pathogenic B-cell subsets, whereas humoral immunity was impaired only with RTX."
Clinical • Glomerulonephritis • Nephrology • Pediatrics • Renal Disease
|
|
Martina Riganati; Federica Zotta; Antonio Gargiulo; Giorgio Martelli; Ester De Leo; Giulia Ricci; Gianluca Caridi; Xhuliana Kajana; Andrea Angeletti; Felicitas E. Hengel; Nicola M. Tomas; Tobias B. Huber; Francesco Emma; Marina Vivarelli; Manuela Colucci
|