Allograft Recurrence of COVID-19-Associated Seronegative Membranous Nephropathy: Codominant IgA/IgG Deposits and Lectin Complement Pathway Activation (KIDNEY WEEK 2026) - Oct 2, 2026 - Abstract #FR-PO0743; Pres time: Oct 23, 2026; 10:00 AM - 12:00 PM; Location: Exhibit Hall A, Convention Center; "Patient underwent living donor kidney transplantation with thymoglobulin induction and standard maintenance (tacrolimus, MMF, prednisone)...The shift from classical (C1q+) to lectin pathway (C4d+, C1q−) complement activation in the allograft may reflect altered post-transplant immune dynamics; this complement shift may explain rituximab resistance, as lectin pathway activation is independent of B-cell-mediated immunity. This case suggests that COVID-19-associated MN may represent a distinct pathological entity that does not conform to the usual paradigm of primary MN, pointing toward complement-targeted therapy as a rational next step in refractory disease."
Cardiovascular • Coronary Artery Disease • Dyslipidemia • Glomerulonephritis • Hypertension • IgA Nephropathy • Immunology • Infectious Disease • Nephrology • Novel Coronavirus Disease
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Nour Khaled Younis; Ramesh Saxena
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