Acute myeloid leukemia arising in treated chronic lymphocytic leukemia/small lymphocytic lymphoma: a challenge in analysis of lineage relationship. (PubMed, J Hematop) - Sep 20, 2026 - "Herein, we report a 75-year-old female with a history of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) post obinutuzumab and venetoclax therapy, presenting with CD4+/CD56+/CD123+ acute myeloid leukemia (AML) with histiocytic morphology. The unusual morphology triggered a preliminary diagnosis of CLL transdifferentiation to histiocytic sarcoma (HS); however, a comprehensive workup led to the correct diagnosis of de novo AML. This case showcases the utility of ancillary studies in the work up of secondary myeloid neoplasms post B-cell lymphomas and underlines pitfalls to consider for accurate characterization of these complex malignancies."
Journal • Acute Myelogenous Leukemia • B Cell Lymphoma • Chronic Lymphocytic Leukemia • Hematological Malignancies • Leukemia • Lymphoma • Non-Hodgkin's Lymphoma • Oncology • Sarcoma • Small Lymphocytic Lymphoma • Solid Tumor • CD123 • CD4 • IL3RA • NCAM1
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Aruna Rangan; David S Viswanatha; Min Shi; Patricia T Greipp; Paul Ollila; Rong He
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