Abrupt Termination of Severe Treatment Refractory Neuropsychiatric Symptoms in a Patient Treated With Rituximab-A Case Report. (PubMed, Case Rep Psychiatry) - Sep 20, 2026 - "Pharmacologic treatments consisted of multiple trials of different antidepressants and antipsychotics, eventually with a trial of clozapine without notable benefit and further worsening of symptoms. This case illustrates an atypical presentation of treatment-resistant neuropsychiatric and neurocognitive symptoms that benefitted from comprehensive, multidisciplinary evaluation and treatment. When frank antibody-positive autoimmune encephalitis and antibody-negative autoimmune encephalitis have been excluded, clinicians should consider underlying emerging systemic autoimmune disease, for example, SLE as a potential cause of psychosis and other severe neuropsychiatric manifestations, prompting further diagnostic workup and treatment strategies, including immunotherapy."
Journal • CNS Disorders • Cognitive Disorders • Depression • Developmental Disorders • Hematological Disorders • Immunology • Inflammatory Arthritis • Lupus • Major Depressive Disorder • Mood Disorders • Psychiatry • Rheumatology • Schizophrenia • Systemic Lupus Erythematosus
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Brian Rosen; Daniel Albert; Juliette Madan
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