A changing early onset scoliosis phenotype in spinal muscular atrophy: nusinersen treatment is associated with younger age, increased curve magnitude, and kyphosis at the time of index surgery. (PubMed, Spine Deform) - Sep 18, 2026 - "Nusinersen exposure was associated with younger age at surgery, greater curve magnitude, and increased kyphosis. These findings highlight potential changes in the phenotype of surgical candidates with EOS and SMA among patients treated with Nusinersen."
Journal • Genetic Disorders • Movement Disorders • Muscular Atrophy • Pediatrics • Rare Diseases
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Amy McIntosh; Benjamin Roye; Bill Young; Brandon Ramo; Brian Snyder; Daniel Bouton; Ian Hollyer; Jaysson Brooks; John S Vorhies; John Smith; Majella Vaughan; Marleni Albarran; Michael Vitale; Nicole Segovia; Patrick Cahill; Pediatric Spine Study Group; Ron El-Hawary; Talissa Generoso; Xochitl Bryson
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