Structures of the volume-regulated anion channel LRRC8A/D in activating and inhibiting conditions. (PubMed, Nat Commun) - Sep 18, 2026 - "In LRRC8A/D heteromers, the two D subunits weaken the arrangement of A subunits and thus enhance the activation properties of the channel. This channel conformation is strongly perturbed upon binding of the potentiating sybody Sb4, which disrupts the packing of the cytoplasmic domains linking their mobility to pore opening."
Journal • Oncology • LRRC8A
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Dawid Deneka; Elena F Lehmann; Fabienne Stierli; Raimund Dutzler; Sonja Rutz
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