Granulomatous Tubulointerstitial Nephritis (TIN) and Hypercalcemia Revealing Monoclonal B-Cell Lymphocytosis Progressing to Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (KIDNEY WEEK 2026) - Oct 2, 2026 - Abstract #FR-PO0468; Pres time: Oct 23, 2026; 10:00 AM - 12:00 PM; Location: Exhibit Hall A, Convention Center; "Prednisone was initiated with initial resolution of AKI; however, worsened during taper, prompting rituximab initiation. It is classified into low and high-count subtypes based on clonal B-cell burden, with high-count MBL carrying a higher risk of progression to CLL. This case underscores a few key teaching points: (1) MBL warrants ongoing monitoring given potential for progression, (2) unexplained hypercalcemia should prompt evaluation of malignancy including explorative lymph node biopsy, and (3) underlying cause of granulomatous TIN is difficult to pinpoint in patients with multiple etiologies and often requires trial of different treatment regimens."
Chronic Lymphocytic Leukemia • Diabetes • Endocrine Disorders • Hematological Malignancies • Hepatitis B • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Leukemia • Lymphoma • Metabolic Disorders • Nephrology • Non-Hodgkin's Lymphoma • Renal Disease • Sarcoidosis • Sjogren's Syndrome • Small Lymphocytic Lymphoma • Type 2 Diabetes Mellitus • Xerostomia • CD5
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Michael A. Cooper; Zain AlShanableh
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