Successful ABO-incompatible living donor kidney transplantation overcoming an extreme baseline isoagglutinin titer of 1:4096: A case report (TTS 2026) - Sep 17, 2026 - Abstract #P4.721; Pres time: Sep 22, 2026; 04:45 PM - 06:00 PM; Location: Hall 1-2; P4; "The desensitization protocol commenced on day -9 with rituximab (700 mg) and triple oral immunosuppression...Early pharmacokinetic monitoring via area under the curve (AUC) assessments for tacrolimus and mycophenolate mofetil was utilized to optimize exposure in this high-risk setting... ABOi kidney transplantation can be successfully performed despite extreme baseline isoagglutinin titers and perioperative titer rebound. A rigorous, multi-modal desensitization strategy combining IA, DFPP, and aggressive induction, paired with strict postoperative pharmacological and histological surveillance, can prevent hyperacute rejection and achieve excellent early allograft outcomes. High baseline and transplant-day anti-ABO titers do not always preclude transplantation."
Case report • Clinical • Antibody-mediated Rejection • Nephrology • Transplant Rejection • Transplantation
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Salin Wattanatorn1; Wipada Songwattana1; Veerapat Wattanasatja1; Suwasin Udomkarnjananun1
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