Metagenomic Deep Sequencing Identifies Gene Mutations Associated with Chemotherapeutic Resistance in Vitreoretinal Lymphoma. (PubMed, Ocul Immunol Inflamm) - Sep 18, 2026 - "Four specimens from three patients harbored mutations associated with methotrexate resistance, the mainstay of VRL treatment...Despite multi-agent therapy including rituximab, consolidation regimens, and lenalidomide, this patient ultimately succumbed to the disease, whereas the other three patients remained in long-term remission...The ability to easily sample ocular fluid and detect different mutations associated with tumor recurrence or persistence may provide insights into tumor pathogenesis and could inform prognosis and influence treatment decisions. These findings establish a foundation for developing targeted PCR assays for identified resistance genes, which could transform clinical practice in VRL."
Journal • CNS Lymphoma • Hematological Malignancies • Lymphoma • Oncology • MYD88
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Armin Hinterwirth; Jay M Stewart; John A Gonzales; Thananop L Pothikamjorn; Thuy A Doan
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