Mapping Kidney Trait Heritability to Individual Cells Reveals Disease-Specific Remodeling of Genetic Risk Architecture (KIDNEY WEEK 2026) - Oct 2, 2026 - Abstract #TH-OR024; Pres time: Oct 22, 2026; 05:20 PM - 05:30 PM; Location: Room 711, Convention Center; "Three therapeutic targets were nominated—PDE4D (roflumilast), ITGB6 (STX-100), and SPP1 (anti-OPN antibody)—each showing disease-specific upregulation in distinct cell populations. Conclusion The Kidney Genetic Disease Cell Atlas provides a resource to define the cellular basis of kidney disease heritability and identify condition-specific therapeutic opportunities. GWAS summary statistics for six kidney traits are processed via MAGMA v1.10; the top 1,000 genes per trait feed scDRS v1.0.2 to score 304,652 cells across five conditions"
Clinical • Acute Kidney Injury • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Genetic Disorders • Glomerulonephritis • IgA Nephropathy • Infectious Disease • Metabolic Disorders • Nephrology • Novel Coronavirus Disease • Renal Disease • Type 2 Diabetes Mellitus • CST3 • ITGB6 • SPP1
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Huiqian Hu; Anindya S. Paul; Jeremy Rubin; Pinaki Sarder
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