Proteinuria Reduction in Nephrotic Syndrome Is Associated with Threshold-Dependent Lipoprotein Changes (KIDNEY WEEK 2026) - Oct 2, 2026 - Abstract #TH-PO0366; Pres time: Oct 22, 2026; 10:00 AM - 12:00 PM; Location: Exhibit Hall A, Convention Center; "It is unclear if reductions in proteinuria lead to continuous improvements in lipids or if a threshold effect exists beyond which further proteinuria reduction confers no additional lipid benefit Methods We studied 22 adults (59% male; age 48 ± 12 years) with membranous nephropathy enrolled in a 2-year treatment trial of rituximab plus cyclosporine. Conclusion Proteinuria was associated with threshold-dependent changes in ApoB-containing lipoproteins, beyond which lipid abnormalities may uncouple from proteinuria and reflect residual ASCVD risk independent of NS. These findings may have implications for the management of lipids in patients with NS."
Atherosclerosis • Cardiovascular • Dyslipidemia • Glomerulonephritis • Metabolic Disorders • Nephrology • Renal Disease • APOB
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Michael Hwang; Rebecca Brown; Sungyoung Auh; Maureen Sampson; Lilian Howard; Meryl Waldman
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