Brain-resident myeloid cells promote rapid leukocyte adhesion in leptomeningeal vessels after anti-Aβ immunotherapy. (PubMed, bioRxiv) - Oct 2, 2026 - "Anti-Aβ antibodies, including aducanumab and lecanemab, rapidly initiated microglial activation and spatial reorganization within 24 hours of dosing, with recruitment to plaque-associated regions, stabilizing plaque growth...Prophylactic treatment with high-dose dexamethasone reduced the number of adherent cells without affecting microglial activation...These findings demonstrate that anti-Aβ immunotherapy rapidly initiates a coordinated central and peripheral immune response at the leptomeningeal interface. These early immune-vascular interactions represent a plausible initiating mechanism for ARIA and provide a mechanistic framework to guide strategies for mitigating ARIA risk."
Journal • Alzheimer's Disease • CNS Disorders
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Aryan Rajput; Brian J Bacskai; Joseph El Khoury; Katy R Walsh; Kivilcim Kilic; Lakshita Palanivelu; Maria V Sanchez-Mico; Mariel G Kozberg; Moustafa Algamal; Patrick da Silva; Rebecca Gillani; Saef Izzy; Sarena Abdallah; Shinya Yokomizo; Sunny Kumar; Wadzanai Ndambakuwa; Yuna Lee
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