Childhood-Onset Systemic Lupus Erythematosus: Genetic Mechanisms and Therapeutic Strategies. (PubMed, Immunol Invest) - Oct 2, 2026 - "Therapeutically, belimumab, telitacicept, anifrolumab, JAK inhibitors, rituximab and emerging CAR-NK therapy are shifting treatment toward precision targeting, with genotype-guided therapy showing notable success in monogenic lupus. Major challenges persist, including scarce pediatric-specific trials, delayed translation of genetic findings, heterogeneous treatment responses, and unknown long-term safety. Addressing these gaps through multicenter cohorts, pediatric-specific randomized controlled trials, and biomarker-driven algorithms will transform cSLE management from adult-data extrapolation to molecular subtyping and tailored therapy."
Journal • Review • Glomerulonephritis • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Pediatrics • Systemic Lupus Erythematosus
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Lifang Zhang; Weiqun Bao; Xulai Shi; Yiming Tong; Yuxing Shi; Zaiquan Shi
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