GCF-anchored and target-oriented mining of metagenomic BGC space for bioactive product discovery. (PubMed, Microbiol Spectr) - Oct 2, 2026 - "Applying metasynBGC to large-scale public metagenome-assembled genome (MAG) data sets, we uncovered hidden biosynthetic potential, including BGC0001089_plus, a novel bacillaene-like variant containing an additional functional pksF gene...We demonstrate its efficacy by identifying and synthesizing novel compounds with notable cytotoxic activity, providing a validated "sequence-to-molecule" pipeline. This work offers a scalable framework for the systematic discovery of therapeutic candidates from uncultivated microbes and expands our capacity to interpret genomic "dark matter." By enabling the functional validation of complex molecules from fragmented data, metasynBGC facilitates the translation of metagenomic data sets into promising leads for therapeutic development."
Journal • Oncology
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Guoping Zhao; Haokui Zhou; Jiacheng Wu; Lanlan Zhao; Lei Zhang; Mingjing Luo; Tao Wang; Xiao Yang; Xiuxiu Xie; Yaxuan Xi; Ziyun Li
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