Diagnostic Uncertainty in Rapidly Progressive Brainstem Lesions: A Radiological Diagnosis of Probable CNS Relapse of Diffuse Large B-cell Lymphoma. (PubMed, Cureus) - Oct 1, 2026 - "We present the case of a 78-year-old woman with a history of diffuse large B-cell lymphoma (DLBCL), previously treated as per the REMoDL-B (Randomised Evaluation of Molecular-Guided Therapy for Diffuse Large B-cell Lymphoma With Bortezomib) protocol with rituximab, bortezomib, cyclophosphamide, doxorubicin, vincristine, and prednisolone, alongside intrathecal methotrexate for CNS prophylaxis, who presented 10 years after achieving systemic remission with a 15-day history of hyperactivity, choreiform movements, pressured speech, and incontinence...Repeat MR imaging of the head was performed after the patient deteriorated clinically despite empirical treatment for infective encephalitis with intravenous ceftriaxone and aciclovir...Given an Eastern Cooperative Oncology Group (ECOG) performance status of 4, the patient was not a candidate for treatment and was discharged on a palliative pathway. This case highlights three key learning points: CNS relapse of DLBCL..."
Journal • B Cell Lymphoma • Bipolar Disorder • CNS Disorders • CNS Lymphoma • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Immunology • Lymphoma • Mood Disorders • Movement Disorders • Non-Hodgkin's Lymphoma • Oncology
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Brett Ibbeson; Pranav Santhosh Kumar; Tom Bull; Yik Shun Eason Chan
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