Refractory C3 Glomerulonephritis with Rapid Clinical and Biochemical Response to Pegcetacoplan After Failure of Eculizumab and Mycophenolate (KIDNEY WEEK 2026) - Oct 2, 2026 - Abstract #SA-PO0708; Pres time: Oct 24, 2026; 10:00 AM - 12:00 PM; Location: Exhibit Hall A, Convention Center; "She was treated with Prednisone and Mycophenolate. In contrast, proximal C3 inhibition with Pegcetacoplan leads to a reduction in ongoing C3 consumption, resulting in rapid normalization of C3 and subsequently clinical improvement with reduction of proteinuria and hematuria. This case highlights the limitations of terminal complement inhibition in C3GN and supports proximal complement inhibition as a better therapeutic strategy in patients with C3GN"
Clinical • Cardiovascular • Complement-mediated Rare Disorders • Glomerulonephritis • Hypertension • Lupus Nephritis • Nephrology • Renal Disease
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