Lower baseline cerebrospinal fluid amyloid-β 42 is associated with amyloid-related imaging abnormalities during real-world lecanemab treatment. (PubMed, J Alzheimers Dis) - Sep 16, 2026 - "Aβ40 was also lower, whereas the Aβ42/Aβ40 ratio was not significantly different and tau biomarkers were not higher. Lower Aβ42 was associated with subsequent ARIA, but the internally derived cutoff requires external validation."
Journal • Real-world evidence • Alzheimer's Disease • CNS Disorders • Aβ42
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Akira Hashiramoto; Eiji Mizuta; Hisatomo Kowa; Jun Fujita; Kohsuke Yoshida; Ryuichi Takahashi; Tetsuo Kashibayashi
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