Rituximab and corticosteroids for M-protein-negative PGNMID: case report. (PubMed, BMC Nephrol) - Oct 24, 2026 - "PGNMID should be considered in rapidly progressive glomerulonephritis, even when M-protein is negative. In this patient, a single reduced dose of rituximab combined with prolonged corticosteroids was associated with a favorable renal outcome, suggesting that a B-cell-directed, clone-directed approach may be a reasonable option worth further evaluation in seronegative PGNMID. Nonetheless, causality cannot be established from a single case, and the relative contributions of the individual therapies remain uncertain. Further studies are needed to define the optimal treatment for this rare entity."
Journal • Glomerulonephritis • Infectious Disease • Lupus Nephritis • Nephrology • Renal Disease • Respiratory Diseases • Septic Shock
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Fengying Tang; Jun Cai; Shuopeng Yang; Zhuolin Huang
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