Influence of the Neuroactive Steroids Allopregnanolone and Zuranolone on Inhibitory Neurotransmission and Synaptic Organization in the context of GlyR autoantibodies (Neuroscience 2026) - Sep 27, 2026 - Abstract #PSTR299.06 / K7; Pres time: Nov 18, 2026; 08:00 AM - 12:00 PM; Location: WCC Halls A-C; "GlyR autoantibodies are known to reduce glycinergic inhibition, specifically glycine potency. Our data thus far indicate that patient-derived autoantibodies induce an increase in excitation that can be partially counteracted by the application of NAS, highlighting their potential as pharmacological agents against neurological diseases affecting the inhibition-excitation balance."
CNS Disorders • Depression
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J. NAUSESTER1; M. HABIB1; S. CAMUSO2; A. PIANOS2; C. SPECHT2; C. VILLMANN1
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