Long-term clinical and biomarker observations following rituximab exposure in two siblings with CSF1R-related leukoencephalopathy: a preliminary familial case series. (PubMed, Commun Med (Lond)) - Oct 3, 2026 - "In this preliminary familial case series of two siblings carrying the same CSF1R variant, RTX exposure was followed by long-term clinical stability and favorable biomarker trajectories. Patient 1 had a pre-treatment disease course of approximately 13 years, indicating an inherently slow disease progression that cannot be entirely separated from the treatment effect in an uncontrolled observation."
Biomarker • Journal • CNS Disorders • Inflammation • CD20 • CSF NfL • CSF1R • CXCL13 • IL6 • NEFL
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Goda-Camile Mickeviciute; Jinming Han; Lidija Marija Smertinaite; Mourad Kourie; Nadezda Zhuravleva; Ramojus Balevicius; Robert Harris; Tobias Granberg; Virginija Danylaite Karrenbauer; Zbigniew Wszolek
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