Serum p-tau181 and p-tau217 levels in adolescents and adults with 5q spinal muscular atrophy. (PubMed, J Neurol) - Oct 23, 2026 - "Serum p-tau181 and p-tau217 appear to reflect ongoing muscle turnover in adult SMA, declining as muscle mass decreases. Higher baseline p-tau181 was associated with subsequent functional deterioration, suggesting potential utility as a biomarker of active denervation and disease monitoring."
Biomarker • Journal • Retrospective data • Alzheimer's Disease • Amyotrophic Lateral Sclerosis • CNS Disorders • Genetic Disorders • Movement Disorders • Muscular Atrophy • Rare Diseases • NEFL • p-tau181
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Alexander Mensch; Andreas Roos; Anna Kölsch; Arthur Guthknecht; Caroline Deborah Stapf; David Strube; Jochen Weishaupt; Kathleen Kleeberg; Kristl G Claeys; Lorenzo Barba; Louise Iterbeke; Markus Otto; Petra Steinacker; Samir Abu-Rumeileh; Thomas Kendzierski; Zeljko Uzelac
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