Successful Rescue of a Kidney Allograft from De Novo C3 Glomerulonephritis with Pegcetacoplan (KIDNEY WEEK 2026) - Oct 2, 2026 - Abstract #FR-PO1156; Pres time: Oct 23, 2026; 10:00 AM - 12:00 PM; Location: Exhibit Hall A, Convention Center; "Standard management with terminal complement blockade agents such as eculizumab often fail to halt the proximal complement dysregulation that drives persistent C3 deposition and glomerular injury. This case demonstrates that proximal inhibition with pegcetacoplan can effectively interrupt alternative pathway activation, leading to rapid recovery and dialysis independence. To our knowledge, this is one of the first reports of successful de novo C3GN treatment using this approach Immunoflorescnece showing C3 deposition"
Acute Kidney Injury • Chronic Kidney Disease • Complement-mediated Rare Disorders • Diabetes • Diabetic Nephropathy • Glomerulonephritis • Lupus Nephritis • Metabolic Disorders • Nephrology • Type 2 Diabetes Mellitus
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Naseer Khan; Irfan Agha; Haris Farooq Murad; Sara Roshan; Hamza Ahmad
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