Recurrent Type 1 IgM Cryoglobulinemic Membranoproliferative Glomerulonephritis (MPGN) After Kidney Transplantation (KIDNEY WEEK 2026) - Oct 2, 2026 - Abstract #FR-PO1157; Pres time: Oct 23, 2026; 10:00 AM - 12:00 PM; Location: Exhibit Hall A, Convention Center; "Case Description A 72 yr old woman with ESRD from type 1 IgM κ cryoglobulinemic MPGN due to Waldenström macroglobulinemia was treated with melphalan/rituximab/steroids (partial response), then ibrutinib, achieving a 4 yr complete response but ultimately progressed to ESRD ~15 yrs after diagnosis. She underwent a preemptive DDKT with basiliximab induction and TAC/MPA/Pred maintenance...She was treated with rituximab, bendamustine, and steroids, improving SCr to 1.8 mg/dL...B & C: IF showing IgM κ–restricted staining within the pseudothrombi. D: EM demonstrating numerous cryoglobulin deposits in glomerular capillary lumens."
B Cell Lymphoma • Chronic Kidney Disease • Glomerulonephritis • Hematological Disorders • Hematological Malignancies • Lupus Nephritis • Lymphoma • Lymphoplasmacytic Lymphoma • Nephrology • Non-Hodgkin's Lymphoma • Transplantation • Waldenstrom Macroglobulinemia • CD5 • MME
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Zainulabdeen S. Alsaedi; Guilherme Gomide Almeida; Hamza Ikrai; Nidia Cordeiro Messias; Naoka Murakami; Massini Merzkani
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