Juvenile Systemic Sclerosis in a Single Center: Clinical Features, Capillaroscopic Findings, Immunological Profile, and Treatment Outcomes-A Retrospective Descriptive Analysis. (PubMed, Children (Basel)) - Sep 27, 2026 - "Two first-line regimens were compared: glucocorticosteroids with penicillamine (PA, n = 19) versus glucocorticosteroids with DMARDs (methotrexate, mycophenolate mofetil, or cyclophosphamide; n = 21). ILD and J4S > 15 were associated with escalation to biologic therapy, and earlier switching to rituximab may be beneficial in refractory patients. Future prospective multicenter studies are needed to validate these findings."
Journal • Retrospective data • Cardiovascular • Immunology • Interstitial Lung Disease • Pediatrics • Pulmonary Disease • Respiratory Diseases • Rheumatology • Scleroderma • Systemic Sclerosis
|
|
Elena Afonina; Elizaveta Aseeva; Maria Osminina; Marina Kuzina; Nadezhda Podchernyaeva; Natalia Geppe; Pavel Berezhanskiy; Pavel Moldon; Petr Ermolinskiy; Svetlana Chebysheva; Vera Podzolkova; Viktoria Soboleva; Vladimir Volnukhin; Vyshakie Puvaneswaran; Yulia Kostina
|