Differentiated LUHMES Cells as a Model to Investigate Neurotropic Arboviruses and Evaluate Host-Directed Therapeutics. (PubMed, Microorganisms) - Sep 27, 2026 - "We also demonstrated how the model may be applied to evaluate potential therapeutic options using an FDA-approved small molecule, Omaveloxolone. Finally, we analyzed host cell responses to infection and treatment using gene expression and phospho-signaling analyses. These findings highlight the value of this model to interpret the pathogenic mechanisms of neurotropic viral infections and evaluate potential therapeutic intervention strategies in a clinically relevant in vitro human neuronal model."
Journal • CNS Disorders • Dengue Fever • Infectious Disease
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Aarthi Narayanan; Alison Gomeiz; Dylan Valerio Scarton; Elsa Ronzier; Jonathan Ontivero Sanchez; Lorreta Aboagyewa Opoku; Maame Konadu; Mariaelena Pierobon; Michael D Barrera; Rémi Veneziano; Shannon D Walls; Stephanie V Trefry
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