A gut microbiota-metabolite-host gene score for subtyping and predicting the treatment response in rheumatoid arthritis: integrative analysis with in silico knockout validation. (PubMed, Bioresour Bioprocess) - Oct 21, 2026 - "This study establishes a GMS based on the gut microbiota-metabolite-host gene regulatory axis as a robust tool for molecular subtyping and predicting biological therapy responses in patients with RA. Crucially, through integrated computational modelling, including in silico knockout and molecular docking validation, we identified FOS/JUN as critical executor genes linking the gut microenvironment to RA bone destruction, providing novel targets for therapeutic strategies aimed at the gut-joint axis."
IO biomarker • Journal • Immunology • Inflammatory Arthritis • Metabolic Disorders • Rheumatoid Arthritis • Rheumatology • EGFR • IDO1 • JUN
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Chen-Long Li; Qi Wang; Qi Yu; Tai Huang; Xiang-Fei Sun; Yi-Jie Yang
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