Adult-onset Still Disease Flare 5 Days Following Poly-l-lactic Acid Injection: A Cautionary Tale for Aesthetic Practice. (PubMed, Plast Reconstr Surg Glob Open) - Oct 18, 2026 - "We report a 57-year-old woman with AOSD, previously stable on annual rituximab (1 g), who developed a severe systemic flare temporally associated with a poly-l-lactic acid facial injection, with symptom onset 5 days after the procedure...This case raises the possibility that collagen-stimulating biomaterials may act as an immunological trigger for systemic autoinflammatory relapse in predisposed patients; however, causality cannot be inferred from a single observation, and the relationship described here is strictly temporal. As a conceptual, hypothesis-generating proposal, a structured preprocedural risk assessment and multidisciplinary perioperative protocol are suggested for consideration before elective aesthetic procedures in AOSD patients, pending validation in larger series."
Journal • Aesthetic Medicine • Immunology • Inflammation • Rheumatology • CRP
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Faris Aldaghri; Lama A Alkhwildi
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