Comparator Event Rates, Baseline Activity, and Operational Selection Pressure in Relapsing Multiple Sclerosis Trials: A Meta-Epidemiological Analysis. (PubMed, Eur J Neurol) - Oct 11, 2026 - "Lower baseline relapse activity accompanied declining event yield. OSPI made a treatment-ecosystem transition measurable but could not be separated from calendar era or establish mechanism. Trials require conservative event assumptions, harmonized reporting, and validation using screening and country- or period-specific outcomes."
Clinical • Journal • CNS Disorders • Multiple Sclerosis
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Hans-Peter Hartung; Lars Masanneck; Marc Pawlitzki; Steffen Pfeuffer
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