Rare Concurrent IgAN and Primary FSGS in a Solitary Kidney: A Proliferation-Inducing Ligand Inhibition as a Unified Long-Term Management Strategy (KIDNEY WEEK 2026) - Oct 2, 2026 - Abstract #PUB134; "We present a case where multicomorbidity led to selection of sibeprenlimab, a conditionally approved anti-APRIL monoclonal antibody, as long-term monotherapy...Prednisone and rituximab reduced UPCR from 18 to 0.66 g/g, but steroids were tapered urgently due to steroid adverse effects...The PIONEER basket trial is actively investigating atacicept, a dual BAFF/APRIL inhibitor, in immune-mediated FSGS...Toluidine blue: segmental sclerosis with endocapillary foam cells B. Antigen-retrieved paraffin IgA stain: segmental granular mesangial staining C-E. Diffuse foot process effacement & mesangial electron-dense deposits"
Cardiomyopathy • Cardiovascular • Chronic Kidney Disease • Fibrosis • Focal Segmental Glomerulosclerosis • Glomerulonephritis • Hypertrophic Cardiomyopathy • IgA Nephropathy • Immunology • Nephrology • Obstructive Hypertrophic Cardiomyopathy • Renal Disease
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Justin Krafft; Mohammad Obeidat; Nathaniel Reisinger
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