Integrated multiomics identifies inhibitors of apoptosis (IAPs) and death-inducing signaling complex (DISC) components as novel vulnerabilities to overcome immune evasion in TP53-inactivated Acute Myeloid Leukemia

Venclexta (venetoclax) - Roche, AbbVie

birinapant (IGM-9427) - IGM Biosciences

tolinapant (ASTX660) - Otsuka

emricasan (IDN 6556) - Amerimmune

https://meetings-api.hematology.org/api/abstract/vmpreview/292043

Jordan Yong Ming Tan1; Chuqi Wang1; Clara Kai Ting Koh2; Yash Manish Agrawal3; Wen Kang Soh1; Fang Qi Lim1; Yuhan Wang1; Nishtha Chitkara4; Xiao Xian Lin1; Jia Chi Tan2; Ahmed M Mamdouh1; Gloryn Chia1; Nicholas RJ Gascoigne5; Shruti Bhatt1,6

Nov 4, 2025