Sequential modulation of the cGAS-STING pathway promotes spinal cord injury repair. (PubMed, J Adv Res) - Oct 10, 2026 - "The cGAS-STING pathway exerts phase‑dependent, biphasic functions in SCI. A precisely timed "activation followed by inhibition" strategy optimally harnesses myeloid cell dynamics to coordinate debris clearance and inflammation resolution, offering a novel immunomodulatory paradigm for central nervous system repair."
Journal • CNS Disorders • Immunology • Inflammation • Orthopedics
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Changlai Zhu; Hui Li; Ling Luo; Lü Chen; Maolin Han; Min Yuan; Qianqian Peng; Shirong Wen; Xin Wu; Yun Gu
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