Hepatocellular carcinoma-derived lactate-mediated histone H3K18 lactylation modifies S100A2 transcription to promote proliferation, migration, invasion and epithelial-mesenchymal transition of hepatocellular carcinoma cells (PubMed, Nan Fang Yi Ke Da Xue Xue Bao) - Oct 1, 2026 - "HCC-derived lactate enhances H3K18la modification, which activates S100A2 transcription to positively regulate the Wnt/β‑catenin pathway, ultimately promoting the proliferation, migration, invasion and EMT of HCC cells."
Journal • Hepatocellular Cancer • Oncology • Solid Tumor • CDH1 • KRT6A • VIM
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Jingping He; Liping Huang; Wanbing Zhou; Yu Shao
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