Impact of Spatial Resolution on 177 Lu Dosimetry: A Pharmacokinetic Digital Phantom Study Demonstrating that Resolution-Induced TIA Errors Dictate Absorbed Dose (EANM 2026) - Sep 29, 2026 - Abstract #EP-1017; "Materials and A digital phantom with exact ground truth (GT) activity concentrations for six time points (1-144 h) was constructed based on the ICRP 110 reference model and a 177Lu-DOTATATE pharmacokinetic model... This study mathematically formulates the systematic underestimation of 177Lu dosimetry caused by degraded spatial resolution. The perfect convergence of TIA and AD recovery coefficients proves that the magnitude of dosimetry errors is predominantly determined during the upstream TIA quantification stage. Therefore, ensuring accurate TIA through resolution recovery and partial volume correction is a fundamental prerequisite for reliable personalized dosimetry, regardless of the downstream dose calculation algorithms employed."
PK/PD data
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T. Ogino; S. Ito; K. Onuma; T. Kita; F. Sasaki; H. Sagara; M. Sato; H. Daisaki
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