Cycle-dependent shift in optimal acquisition window for single-time-point tumor dosimetry in [ 177 Lu]Lu-PSMA therapy (EANM 2026) - Sep 29, 2026 - Abstract #EP-1011; "The selected structural model and its population priors (fixed effects, inter-individual variability, and residual error variance), were applied to a retrospective clinical dataset of patients with metastatic castration-resistant prostate cancer treated with up to four cycles of [177Lu]Lu-PSMA-617... The optimal STP acquisition window for tumor dosimetry in [177Lu]Lu-PSMA therapy is cycle-dependent, shifting from early to later point across RPT cycles. These findings demonstrate that fixed STP imaging protocols may introduce systematic bias and support the use of cycle-adaptive, model-informed strategies to maintain dosimetry accuracy while reducing patient burden."
Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor
|
|
N. Cavedini 1, 2; V. Zolkina 2; A. Riznychenko 2; U. Nemer 3; W. Noordzij 2; A. Marques da Silva 4; C. Moriguichi Jeckel 1; M. Mix 3; O. Ivashchenko 2
|