Diagnostic Value of Skin Biopsy in Fatal Histoplasmosis-Associated Hemophagocytic Lymphohistiocytosis: A Case Report. (PubMed, Dermatol Ther (Heidelb)) - Oct 14, 2026 - "In patients with HLH, subtle skin lesions may provide accessible tissue for demonstrating invasive infection and obtaining organism-specific confirmation, even when fungal staining of another tissue is negative. Careful skin examination and targeted biopsy of new, atypical, or evolving lesions should be considered in immunocompromised adults with unexplained systemic inflammation, particularly those receiving tumor necrosis factor-alpha inhibitors."
Journal • Dermatology • Dyslipidemia • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Hypertriglyceridemia • Immunology • Infectious Disease • Oncology • Psoriasis • Rare Diseases
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Claudia Lee; Jaclyn Roland-McGowan; Jesse J Keller; Riyad N H Seervai; Stephanie Mengden Koon
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