Avastin (bevacizumab) - Roche
Lucentis (ranibizumab) - Roche, Novartis
Visual and anatomical outcomes of early versus delayed anti-VEGF switching after bevacizumab loading in diabetic macular oedema. (PubMed, Eur J Ophthalmol) - Oct 20, 2026 - "An observed-timing comparison excluded eyes switched at months 4-5 (n = 7) and compared early switch (month 3; n = 37) with delayed switch (month ≥6; n = 43) to aflibercept 2 mg or ranibizumab. Total injections numbered 11.2 ± 2.4 versus 14.5 ± 2.6.ConclusionsEarlier switching was associated with greater anatomical improvement in both analyses. A 24-month visual advantage was not demonstrated, although a clinically meaningful benefit could not be excluded." 
Journal • Diabetic Macular Edema • Macular Edema • Ophthalmology
http://www.ncbi.nlm.nih.gov/pubmed/42895767
 
Busra Turpcuoglu; Dogukan Temel; Furkan Karagoz; Kemal Tekin; Kuddusi Teberik; Merve Inanc Tekin; Rukiye Kilic Ucgul
 
Oct 20, 2026
 
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