Non-Surgical Therapies for Knee Osteoarthritis: Current Evidence and Emerging Strategies. (PubMed, Indian J Orthop) - Oct 20, 2026 - "Disease-modifying osteoarthritis drugs (DMOADs), including sprifermin, lorecivivint, LNA043, cathepsin-K inhibition, ADAMTS-5 inhibition, and repurposed metabolic agents such as metformin, are emerging investigational strategies with variable structural and symptomatic results. Non-surgical management of knee OA should follow a stepwise approach, with rehabilitation and weight optimization as first-line therapy, selective injection- and device-based options for persistent symptoms, and timely surgical referral when disability remains refractory. Future progress will depend on standardized protocols and higher-quality long-term comparative trials to improve treatment selection and disease modification."
Journal • Review • Immunology • Orthopedics • Osteoarthritis • Pain • Rheumatology • ADAMTS5 • CTSK
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Elie Mansour; Ghadi Dagher; Guy Awad; Labib Chebli; Marc Boutros; Sofia Habib; Yasha Habis
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