Practical synthesis of 3-Oxa/Aza-bicyclo[3.1.1]heptanes from 3-Oxa/Aza[3.1.1]propellanes. (PubMed, Nat Commun) - Oct 19, 2026 - "Furthermore, representative 3-oxa-BCHep derivatives are converted into functionalized synthetic building blocks; this scaffold is also introduced into the antiepileptic drug URB597 and anticancer drug sonidegib. These results demonstrate that the 3-oxa/aza[3.1.1] frameworks provide a general and feasible synthetic platform for the construction of heteroatom-containing cage-like bioisosteres and the optimization of drug properties."
Journal • Oncology
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Dong Xue; Fang Lei; Huaming Sun; Jianyang Dong; Juan Fan; Mingxin Li; Qin Jiang; Shuoyi Chen; Ting Li; Yanfeng Han; Yilin Zhang; Zhendan Chen
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