OptimUM-09 Follow-Up in Neoadjuvant Primary Uveal Melanoma (PRNewswire) - Oct 19, 2026 - "The primary endpoints for these cohorts are eye preservation rate and planned radiation dose reduction, respectively....Tumor shrinkage of ≥20% was observed in 57.8% (67/116) of patients, including 51.5% (34/66) in Cohort 1 and 66% (33/50) in Cohort 2; notably, data presented from OptimUM-09 at ESMO in 2025 showed that patients who achieved a ≥20% level of tumor shrinkage had a higher rate of eye preservation and improved visual outcomes compared to those below that threshold. Here, a 57% eye preservation rate was observed in the enucleation cohort, and 66% of patients in the plaque brachytherapy cohort had a reduction in planned radiation dose to critical eye structures, with early outcomes data suggesting no detriment from delayed primary local therapy compared to historical recurrence rates."
P2 data • Uveal Melanoma
|