CFD-DEM simulation of capsule vibration facilitated powder discharge and dispersion in Breezhaler. (PubMed, Int J Pharm) - Oct 21, 2026 - "This study presents a computational fluid dynamics-discrete element method (CFD-DEM) investigation on drug discharge and dispersion processes driven by capsule rotation and capsule-device collisions in Ultibro® Breezhaler®, where a layering dynamic mesh method is employed to characterize the capsule's complex rotational and vibrational motions, and a multi-scale model is adopted to evaluate the powder dispersion performance by predicting the fine particle fraction (FPF) based on carrier particle-wall collisions...The predicted FPFemitted values for cases incorporating either continuous or intermittent capsule vibration regimes show good agreement with the experimental data, while the value for the none capsule vibration case is markedly lower. This highlights the necessity of incorporating the capsule vibration into the CFD-DEM model and validates the applicability of multi-scale model for predicting powder dispersion performance in the..."
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Guozhen Li; Jie Dong; Kaiqi Shi; Philip Hall; Qi Yang; Runda Xue; Zheng Wang
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