Sacubitrilat exerts potent antiarrhythmic effects through activation of natriuretic peptide receptor-C. (PubMed, ESC Heart Fail) - Oct 17, 2026 - "These data indicate that activation of NPR-C is both necessary and sufficient for the potent antiarrhythmic actions of sacubitrilat, mediating a selective reduction of arrhythmogenic SR Ca2+ leak in murine ventricular cardiomyocytes as well as in a cellular model of human AIC in iPSC-CM. NPR-C therefore emerges as a promising molecular target for the development of novel antiarrhythmic therapies suitable for patients with heart failure and arrhythmia-induced cardiomyopathy."
Journal • Cardiomyopathy • Cardiovascular • Heart Failure
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Christoph Maack; Jonas Herting; Katrin Streckfuss-Bömeke; Lisa Krebes; Luca F Gerres; Manuel J Vogel; Michael Kohlhaas; Michaela Kuhn; Sabine Rebs; Stefan Frantz; Thomas H Fischer; Thomas Müller
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