Berberine inhibits gastric cancer progression by targeting canonical Wnt/β-catenin signaling in AGS cells. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - Oct 9, 2026 - "CHIR99021 partially reversed berberine-induced anti-tumor effects, whereas XAV939 and CTNNB1 knockdown mimicked or enhanced berberine activity. Berberine suppresses AGS GC cell progression by inhibiting canonical Wnt/β-catenin signaling, thereby reducing proliferation, EMT, invasion, metabolic activity, and survival while promoting cell cycle arrest and apoptosis."
Journal • Gastric Cancer • Oncology • Solid Tumor • BIRC5 • CCND1 • CDH1 • CDH2 • MMP9 • SNAI2 • VIM • ZEB1
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Bai Jing; Li Xiao; Ren Hui
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