Anti-c-Mpl antibody-positive acquired amegakaryocytic thrombocytopenia with immune thrombocytopenia-like features in mixed connective tissue disease. (PubMed, Mod Rheumatol Case Rep) - Oct 2, 2026 - "Although she was initially treated for presumed immune thrombocytopenia with platelet transfusion, prednisolone, and intravenous immunoglobulin, followed by intravenous methylprednisolone pulse therapy, her platelet count failed to improve...Treatment with rituximab and eltrombopag resulted in rapid platelet recovery, and remission has been sustained for 14 months, including after two maintenance rituximab doses administered during follow-up...The markedly elevated immature platelet fraction and platelet-associated immunoglobulin G also raised the possibility of concomitant immune thrombocytopenia-like peripheral platelet destruction. This case highlights the importance of considering acquired amegakaryocytic thrombocytopenia in patients with systemic autoimmune disease and severe thrombocytopenia refractory to corticosteroids or intravenous immunoglobulin, while recognizing that impaired platelet production and peripheral platelet destruction may overlap."
Journal • Hematological Disorders • Hematological Malignancies • Immune Thrombocytopenic Purpura • Immunology • Leukemia • Myelodysplastic Syndrome • Oncology • Rheumatology • Thrombocytopenia • Thrombocytopenic Purpura
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Hiroshi Nakajima; Kodai Kato; Shuhei Kameda; Shunjiro Kurihara; Tatsuya Ueno
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